This limits the user from being able to manage their emails when their computer is not with them. Although there are many advantages in using an email client software, they are however tied to the computer that you installed to.
As for Windows users, they are able to download and use the Windows Live Mail provided by Microsoft for free which replaces the old Outlook Express. There are quite a few email client software and Microsoft Outlook which comes together with Microsoft Office is one of the most used email clients in corporate environments due to its powerful features. Another advantage in using an email client software is you are able to access the downloaded emails and view them in offline mode which is very useful if you do not have an Internet connection at that time. It also allows you to send out emails by just launching the program without going through your web browser and manually logging in. Email client software allows you to easily check all your emails from multiple email accounts by automatically downloading them to your computer via POP3 or IMAP protocol.